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Case Study: Evidence-based approach to accelerating oncology clinical trial recruitment

The Problem

The estimated rates of cancer clinical trial participation among eligible patients remain between 5-7% with limited progress over the past two decades (source). Only 1 in 10 Americans reported ever being invited to participate in a clinical trial (source). Comprehensive efforts to increase access, diversity and overall clinical trial participation are urgently needed.

The Intervention

Lay patient navigators embedded in two NCI-designated Comprehensive Cancer Centers were available to support access to resources that address social determinants of health. An interrupted time series analysis was performed to understand the trends in clinical trial participation at the two centers before and after the intervention was deployed.

The Results

Compared to predicted clinical trial enrollment based on historical data, an increase in clinical trial participation was seen across all oncology therapeutic areas.

Our Strategy

Trial Library’s approach is guided by these data. Trial Library Ally Navigators are diverse, multilingual, and trained in clinical research and cultural competency. Navigators serve as patient advocates, working closely with patients to understand their individual circumstances and help get them to their clinical trial site. Using a tech-enabled communications platform and SDoH resource database, our Navigators are equipped to provide hands-on support to patients to overcome barriers to clinical trial participation.

ITSA with number of participants enrolled in study overall (actual vs predicted)

ITSA with number of participants by trial phase of study (actual vs predicted)

References: ScienceDirect, PubMed

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